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SINEMET may cause a false-positive reaction for urinary ketone bodies when a test tape is used for determination of ketonuriaThis reaction will not be altered by boiling the urine specimenFalsenegative tests may result with the use of glucose-oxidase methods of testing for glucosuria.

Dosage is best initiated with one tablet of SINEMET 25-100 three times a dayThis dosage schedule provides 75 mg of carbidopa per dayDosage may be increased by one tablet every day or every other dayas necessaryuntil a dosage of eight tablets of SINEMET 25-100 a day is reached.

Decreased hemoglobin and hematocritabnormalities in alkaline phosphataseSGOTASTSGPTALTLDHbilirubinBUNCoombs testelevated serum glucosewhite blood cellsbacteriaand blood in the urine.

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when more levodopa is required, sinemet 25 mg 250 mg tablets should be substituted at a dosage of one tablet three or four times a day.

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