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Latanoprost is absorbed through the cornea where the isopropyl ester prodrug is hydrolyzed to the acid form to become biologically active.

Blurred visionburningstingingconjunctival hyperemiaforeign body sensationitchingincreased ocular pigmentationegiriseyelideyelashesmay be permanentpunctate epithelial keratopathyother eyelash/lid changesphotophobiaupper respiratory tract infectionpainanginarashintraocular inflammationmacular edemaincluding cystoid macular edema

The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytesAfter discontinuation of latanoprostpigmentation of the iris is likely to be permanentwhile pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patientsPatients who receive treatment should be informed of the possibility of increased pigmentationBeyond 5 years the effects of increased pigmentation are not knownsee Clinical Studies

If more than one topical ophthalmic medicinal product is being usedthe medicinal products should be administered at least five minutes apart.

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if you are about to be started on any new medicine tell your doctor and pharmacist that you are using xalatan.