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Serum transaminase levels should be measured prior to starting treatment with flutamideFlutamide is not recommended in patients whose ALT values exceed twice the upper limit of normalSerum transaminase levels should then be measured monthly for the first 4 months of therapyand periodically thereafterLiver function tests also should be obtained at the first signs and symptoms suggestive of liver dysfunctionegnauseavomitingabdominal painfatigueanorexiaflu-likesymptomshyperbilirubinuriajaundiceor right upper quadrant tendernessIf at any time a patient has jaundiceor their ALT rises above 2 times the upper limit of normalflutamide should be immediately discontinued with close follow-up of liver function tests until resolution.
Some side effects may require medical attentionOther side effects do not require medical attention and may go away during treatmentPatients should check with their physician about any side effects that continue or are bothersomeWhat can patients do to help alleviate or prevent discomfort and side effects?
What are the less commonoccur in 10to 29of patientsside effects of treatment with flutamide?
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