An older report found bromelain also increased the actions of other antibiotics, including penicillin, chloramphenicol, and erythromycin , in treating a variety of infections.

Chloramphenicol has been shown to cross the placental barrier, but it is not known whether chloramphenicol can cause fetal harm when administered to a pregnant woman.

Erythromycin, clarithromycin, troleandomycin and chloramphenicol inhibit cyp3a metabolism of tacrolimus and may increase tacrolimus whole blood concentrations.

Chloramphenicol is occasionally used in dogs and cats.