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Erythromycin, clarithromycin, troleandomycin and chloramphenicol inhibit cyp3a metabolism of tacrolimus and may increase tacrolimus whole blood concentrations.

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Chloramphenicolantibiotic drug once commonly used in the treatment of infections caused by various bacteriaincluding those in the genera Rickettsia and MycoplasmaChloramphenicol was originally found as a product of the metabolism of the soil bacterium Streptomyces venezuelaeorder Actinomycetalesand subsequently was synthesized chemicallyIt achieves its antibacterial effect by interfering with protein synthesis in these microorganismsIt is seldom used todayhoweverbecause of its potential toxicity and the availability of safer drugs.

Chloramphenicolantibiotic drug once commonly used in the treatment of infections caused by various bacteriaincluding those in the genera Rickettsia and MycoplasmaChloramphenicol was originally found as a product of the metabolism of the soil bacterium Streptomyces venezuelaeorder Actinomycetalesand subsequently was synthesized chemicallyIt achieves its antibacterial effect by interfering with protein synthesis in these microorganismsIt is seldom used todayhoweverbecause of its potential toxicity and the availability of safer drugs.

Medical advice should be sought if there is no improvement in the condition after 2 days or if symptoms worsen at any time.

In severe bacterial conjunctivitis and in cases where infection is not confined to the conjunctivaethe topical use of chloramphenicol should be supplemented by appropriate systemic treatment.

SIDE EFFECTSSide effects of chloramphenicol are headachemental confusionfeverrashdiarrheaand optic atrophy.

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the following information includes only the average doses of chloramphenicol.

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