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Treatment Suggestions for OverdoseThere is no specific antidote for treating overdoses of LIORESAL INTRATHECALbaclofen injectionhoweverthe following steps should ordinarily be undertaken:
Pharmacodynamics of LIORESAL INTRATHECAL Intrathecal BolusAdult PatientsThe onset of action is generally one-half hour to one hour after an intrathecal bolusPeak spasmolytic effect is seen at approximately four hours after dosing and effects may last four to eight hoursOnsetpeak responseand duration of action may vary with individual patients depending on the dose and severity of symptoms.
In patients with epilepsythe clinical state and electroencephalogram should be monitored at regular intervalssince deterioration in seizure control and EEG have been reported occasionally in patients taking Lioresal.
It is mandatory that the patientall patient caregiversand the physicians responsible for the patient receive adequate information regarding the risks of this mode of treatmentAll medical personnel and caregivers should be instructed in 1the signs and symptoms of overdose2procedures to be followed in the event of overdose and 3proper home care of the pump and insertion site.
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