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Many individuals have continued to take proton pump inhibitors long after there is any clearly justified medical reason, which was largely caused by the drug makers failure to warn about the risk of severe injuries associated with long-term use of nexium, prilosec, protonix, prevacid or other ppis.

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Pantoprazole is a PPI that suppresses the final step in gastric acid production by covalently binding to theHKATPase enzyme system at the secretory surface of the gastric parietal cellThis effect leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulusThe binding to theHKATPase results in a duration of antisecretory effect that persists longer than 24 hours for all doses tested20 mg to 120 mg

Pantoprazole sodium is a white to off-white crystalline powder and is racemicPantoprazole has weakly basic and acidic propertiesPantoprazole sodium is freely soluble in watervery slightly soluble in phosphate buffer at pH 7.4and practically insoluble in n-hexaneThe stability of the compound in aqueous solution is pH-dependentThe rate of degradation increases with decreasing pHThe reconstituted solution of Protonix I.Vfor injection is in the pH range 9.0 to 10.5.

Pantoprazole is not removed by hemodialysisIn case of overdosetreatment should be symptomatic and supportive.

3Inspect the diluted Protonix I.Vsolution visually for particular matter and discoloration prior to and during administration.

The safety and effectiveness of Protonix I.Vhave not been established in pediatric patients.

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