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Lef, leflunomide, mtx, methotrexate, ssz, sulphasalazine, plc, placebo.
Information about Methotrexate.
Understanding how methotrexate works helps explain why it can cause unwanted effectsResearchers originally developed methotrexate in the 1940s as a cancer drugIt stops malignantor cancerouscells from rapidly multiplying and spreading by blocking their access to folatea form of vitamin Bwhich these cells need to survive.
100 mg/m2 over 1 hour followed by a 35 hour infusion delivering 900 mg/m2/day.
When methotrexate is less effectiveWhen methotrexate is used with certain drugsit may not work as well to treat your conditionThis is because the amount of methotrexate in your body may be decreasedExamples of these drugs include:
Read the Patient Information Leaflet if available from your pharmacist before you start taking methotrexate and each time you get a refillIf you have any questionsask your doctor or pharmacist.
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abortion, foetal death, and or congenital anomalies have occurred in pregnant women receiving methotrexate, especially during the first trimester of pregnancy.