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Severe heart diseasea history of stroke or blood clotsevere kidney diseasesevere liver diseasea hormone-related cancer such as breast or uterine cancerporphyriaa genetic enzyme disorder that causes symptoms affecting the skin or nervous systemabnormal vaginal bleeding that has not been checked by a doctoror if you are pregnant or breast-feeding.
Your medication needs may change if you become illhave a fever or infectionor if you have surgery or a medical emergencyTell your doctor about any such situation that affects youDo not change your medication dose or schedule without your doctor’s advice.
The following reactions have been reporteda causal relationship to the administration of Danazol has neither been confirmed nor refutedallergicurticariapruritus and rarelynasal congestionCNS effectsheadachenervousness and emotional labilitydizziness and faintingdepressionfatiguesleep disorderstremorparesthesiasweaknessvisual disturbancesand rarelybenign intracranial hypertensionanxietychanges in appetitechillsand rarely convulsionsGuillain-Barre syndromegastrointestinalgastroenteritisnauseavomitingconstipationand rarelypancreatitismusculoskeletalmuscle cramps or spasmsor painsjoint painjoint lockupjoint swellingpain in backneckor extremitiesand rarelycarpal tunnel syndrome which may be secondary to fluid retentiongenitourinaryhematuriaprolonged posttherapy amenorrheahematologican increase in red cell and platelet countReversible erythrocytosisleukocytosis or polycythemia may be provokedEosinophilialeukopenia and thrombocytopenia have also been notedSkinrashesmaculopapularvesicularpapularpurpuricpetechialand rarelysun sensitivityStevens-Johnson syndromeotherincreased insulin requirements in diabetic patientschange in libidoelevation in blood pressureand rarelycataractsbleeding gumsfeverpelvic painnipple dischargeMalignant liver tumors have been reported in rare instancesafter long-term use.
A temporary alteration of lipoproteins in the form of decreased high density lipoproteins and possibly increased low density lipoproteins has been reported during Danazol therapyThese alterations may be markedand prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient.
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allergic bronchopulmonary aspergillosis typi-cally causes an elevated serum eosinophil count cheap danazol 50 mg mastercard, and sputum cultures will test positiveit is very unlikely that there will be fungal tissue invasion.