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Patients taking cytoxan are advised to drink lots of water 8 to 10 glasses per day to help reduce the risk of side effects to the bladder.
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General Disorders and Administrative Site Conditionsmultiorgan failuregeneral physical deteriorationinfluenza-like illnessinjection/infusion site reactionsthrombosisnecrosisphlebitisinflammationpainswellingerythemapyrexiaedemachest painmucosal inflammationastheniapainchillsfatiguemalaiseheadache.
The following adverse reactions are discussed in more detail in other sections of the labeling.
Cyclophosphamide is biotransformed principally in the liver to active alkylating metabolites by a mixed function microsomal oxidase systemThese metabolites interfere with the growth of susceptible rapidly proliferating malignant cellsThe mechanism of action is thought to involve cross-linking of tumor cell DNA.
Cyclophosphamide can cause fetal harm when administered to a pregnant woman and such abnormalities have been reported following cyclophosphamide therapy in pregnant womenAbnormalities were found in two infants and a six-month-old fetus born to women treated with cyclophosphamideEctrodactylia was found in two of the three casesNormal infants have also been born to women treated with cyclophosphamide during pregnancyincluding the first trimesterIf this drug is used during pregnancyor if the patient becomes pregnant while takingreceivingthis drugthe patient should be apprised of the potential hazard to the fetusWomen of childbearing potential should be advised to avoid becoming pregnant.
Patients may experience side effects during administration of cyclophosphamideThese side effects may include hot flushesdizzinessa strange tasterunny eyes and a feeling of having a blocked nosePatients should tell their healthcare provider if they experience any of these symptoms during administration of cyclophosphamideOnce cyclophosphamide is administeredit is eliminated from the body through the kidneys.
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