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In mana single 5-mg oral dose of PROSCAR produces a rapid reduction in serum DHT concentrationwith the maximum effect observed 8 hours after the first doseThe suppression of DHT is maintained throughout the 24-hour dosing interval and with continued treatmentDaily dosing of PROSCAR at 5 mg/day for up to 4 years has been shown to reduce the serum DHT concentration by approximately 70The median circulating level of testosterone increased by approximately 10-20but remained within the physiologic rangeIn a separate study in healthy men treated with finasteride 1 mg per dayn=82or placebon=69mean circulating levels of testosterone and estradiol were increased by approximately 15as compared to baselinebut these remained within the physiologic range.
Physicians should inform patients that the volume of ejaculate may be decreased in some patients during treatment with PROSCARThis decrease does not appear to interfere with normal sexual functionHoweverimpotence and decreased libido may occur in patients treated with PROSCARsee ADVERSE REACTIONS
Bloating or swelling of the facearmshandslower legsor feet breast enlargement and tenderness hives or welts itchy skin rapid weight gain redness of the skin skin rash swelling of the lips and face tingling of the hands or feet unusual weight gain or loss.
In patients receiving PROSCAR 5 mg/dayincreases of about 10were observed in luteinizing hormoneLHand follicle-stimulating hormoneFSHbut levels remained within the normal rangeIn healthy volunteerstreatment with PROSCAR did not alter the response of LH and FSH to gonadotropin-releasing hormone indicating that the hypothalamic-pituitary-testicular axis was not affected.
Finasteride should not be used in womenespecially during pregnancy or breast-feedingIt may harm an unborn or breast-feeding babyConsult your doctor if you have any questions about this medication.
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