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The combination of ZETIA with a statin is contraindicated in patients with active liver disease or unexplained persistent elevations in hepatic transaminase levelsWomen who are pregnant or may become pregnantBecause statins decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterolZETIA in combination with a statin may cause fetal harm when administered to pregnant womenAdditionallythere is no apparent benefit to therapy during pregnancyand safety in pregnant women has not been establishedIf the patient becomes pregnant while taking this drugthe patient should be apprised of the potential hazard to the fetus and the lack of known clinical benefit with continued use during pregnancySee Use in Specific PopulationsNursing mothersBecause statins may pass into breast milkand because statins have the potential to cause serious adverse reactions in nursing infantswomen who require ZETIA treatment in combination with a statin should be advised not to nurse their infantssee Use in Specific PopulationsPatients with a known hypersensitivity to any component of this productHypersensitivity reactions including anaphylaxisangioedemarash and urticaria have been reported with ZETIAsee ADVERSE REACTIONS
You should not use Zetia if you have moderate to severe liver diseaseYou should not use ezetimibe with astatincholesterol medicine if you have active liver diseaseor if you are pregnant or breast-feeding a baby.
For High CholesterolI have tried statins to bring my cholesterol down but the side affects were unbearableHave been on zetia a week and the side affects are insaneMy muscles and joints hurt so bad I want to screamMy skin even burnsGive me high cholesterol over these medications and their side affects any dayI only hope they will go away
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during the trial, hepatic transaminase elevations two consecutive measurements for alt and or ast 3 x uln occurred in four 3 individuals in the zetia coadministered with simvastatin group and in two 2 individuals in the simvastatin monotherapy group.