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For childrenincrease of the dose of lopinavir/ritonavir to 300/75 mg/m 2 twice daily with food should be considered when used in combination with Viramuneparticularly for patients in whom reduced susceptibility to lopinavir/ritonavir is suspected.
To support the use of the prolonged-release tabletsthe company conducted studies to show that the immediateand prolonged-release tablets both had adequate drug levelsand the same effect on the viral load in the bodyStudies were also done to show successful switching from immediate-release tabletstwice daily to prolonged-release tabletsonce daily.
No changes to lamivudine apparent clearance and volume of distributionsuggesting no induction effect of nevirapine on lamivudine clearance.
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