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Tell your doctor right away if any of these rare but very serious side effects occurblack/bloody stoolssevere stomach/abdominal painyellowing eyes or skindark urinemental/mood changesmuscle weakness/spasm.
Cyclophosphamide for InjectionUSPlyophilized powderis a sterile white cake containing cyclophosphamide and mannitol and is supplied in vials for single dose use.
Low-dose500 mg IV every 2 weeks for 6 doses plus corticosteroidsthen maintenance with mycophenolate mofetil or azathioprine.
May dilute further with D5WNSlactated Ringer solutionor other compatible fluids.
Although a few instances of cardiac dysfunction have been reported following use of recommended doses of cyclophosphamideno causal relationship has been establishedAcute cardiac toxicity has been reported with doses as low as 2.4 g/m 2 to as high as 26 g/m 2usually as a portion of an intensive antineoplastic multi-drug regimen or in conjunction with transplantation proceduresIn a few instances with high doses of cyclophosphamidesevereand sometimes fatalcongestive heart failure has occurred after the first cyclophosphamide doseHistopathologic examination has primarily shown hemorrhagic myocarditisHemopericardium has occurred secondary to hemorrhagic myocarditis and myocardial necrosisPericarditis has been reported independent of any hemopericardium.
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okay-so there are multiple drugs that must be given with cytoxan, and i will explain below.