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Mn tatd with Avodat w lss likly txpinc canc pogssion (a wosning thi canc): canc pogssion occud in 38% mn in th Avodat goup and 49% mn in th placbgoup. Mn tatd with Avodat w mlikly thav a inal biopsy that was canc: th biopsy was canc in 36% mn in th Avodat goup and 23% mn in th placbgoup. Mn in th Avodat goup alspotd low lvls postat canc-latd anxity.
Txplwhth Avodat slows canc gowth among mn whchoos activ suvillanc aly postat canc, sachs conductd a study among 302 patints. Mn w assignd tciv ith Avodat a placbth yas. All mn had postat biopsis at th mid-point and nd th study, as ndd.
Mmb, kp this and all oth mdicins out th ach childn, nv sha you mdicins with oths, and us this mdication only th indication pscibd.
In an mbyo-tal dvlopmnt study, pgnant hsus monkys w xposd intavnously ta dutastid blood lvl compaabl tth dutastid concntation ound in human smn. Dutastid was administd on gstation days 20 t100 at doss 400, 780, 1,325, 2,010 ng/day (12 monkys/goup). Th dvlopmnt mal xtnal gnitalia monky osping was not advsly actd. duction tal adnal wights, duction in tal postat wights, and incass in tal ovaian and tstis wights w obsvd at th highst dos tstd in monkys. Basd on th highst masud smn concntation dutastid in tatd mn (14 ng/mL), ths doss psnt 0.8 t16 tims th potntial maximum xposu a 50-kg human mal t5 mL smn daily om a dutastid-tatd man, assuming 100% absoption. (Ths calculations a basd on blood lvls pant dug which a achivd at 32 t186 tims th daily doss administd tpgnant monkys on a ng/kg basis). Dutastid is highly bound tpotins in human smn (gat than 96%), potntially ducing th amount dutastid availabl vaginal absoption. It is not known whth abbits hsus monkys poduc any th majhuman mtabolits.
Th DUC tial was a andomizd, doubl-blind, placbo-contolld tial that nolld 8,231 mn agd 50 t75 yas with a sum PSA 2.5 ng/mL t10 ng/mL and a ngativ postat biopsy within th pvious 6 months. Subjcts w andomizd tciv placb(n = 4,126) 0.5-mg daily doss AVODAT (n = 4,105) up t4 yas. Th man ag was 63 yas and 91% w whit. Subjcts undwnt potocol-mandatd schduld postat biopsis at 2 and 4 yas tatmnt had “o-caus biopsis” at non-schduld tims i clinically indicatd. Th was a high incidnc Glason sc8-10 postat canc in mn civing AVODAT (1.0%) compad with mn on placb(0.5%) [s INDICATIONS AND USAG , WANINGS AND PCAUTIONS ]. In a 7-ya placbo-contolld clinical tial with anoth 5 alpha-ductas inhibit(inastid 5 mg, POSCA), simila sults Glason sc8-10 postat canc w obsvd (inastid 1.8% vsus placb1.1%).
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