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Zoloft sertraline this is an ssri antidepressant that was approved in 1991, and has been among the most successful antidepressants of all time.

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No overall differences in safety or effectiveness were observed between these subjects and younger subjectsand other reported clinical experience has not identified differences in responses between the elderly and younger patientsIn generaldose selection for an elderly patient should be conservativeusually starting at the low end of the dosing rangereflecting the greater frequency of decreased hepaticrenalor cardiac functionand of concomitant disease or other drug therapy.

Are there any other medical conditions that would make someone ineligible for Zoloft therapy?

Inform pregnant women that ZOLOFT may cause withdrawal symptoms in the newborn or persistent pulmonary hypertension of the newbornPPHNSee Use In Specific Populations

Neonates exposed to ZOLOFT and other SSRIs or SNRIs late in the third trimester have developed complications requiring prolonged hospitalizationrespiratory supportand tube feedingThese findings are based on post-marketing reportsSuch complications can arise immediately upon deliveryReported clinical findings have included respiratory distresscyanosisapneaseizurestemperature instabilityfeeding difficultyvomitinghypoglycemiahypotoniahypertoniahyperreflexiatremorjitterinessirritabilityand constant cryingThese features are consistent with either a direct toxic effect of SSRIs and SNRIs orpossiblya drug discontinuation syndromeIn some casesthe clinical picture was consistent with serotonin syndromeSee WARNINGS AND PRECAUTIONS

A study conducted in juvenile rats at clinically relevant doses showed delay in sexual maturationbut there was no effect on fertility in either males or females.

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