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Following oral administration of lisinoprilpeak serum concentrations occur within about 7 hoursalthough there was a trend to a small delay in time taken to reach peak serum concentrations in acute myocardial infarction patientsBased on urinary recoverythe mean extent of absorption of lisinopril is approximately 25with interpatient variability of 6-60over the dose range studied5-80 mgThe absolute bioavailability is reduced approximately 16in patients with heart failureLisinopril absorption is not affected by the presence of food.
Zestril may be used as monotherapy or in combination with other classes of antihypertensive therapysee sections 4.34.44.5 and 5.1
For pediatric patients with glomerular filtration rate30 mL/min/1.73m 2the recommended starting dose is 0.07 mg per kg once dailyup to 5 mg totalDosage should be adjusted according to blood pressure response up to a maximum of 0.61 mg per kgup to 40 mgonce dailyDoses above 0.61 mg per kgor in excess of 40 mghave not been studied in pediatric patientssee Clinical Pharmacology12.3
Take the missed dose as soon as you rememberSkip the missed dose if it is almost time for your next scheduled doseDo not take extra medicine to make up the missed dose.
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