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John s wort, carbamazepine tegretol, and rifampin rifadin will decrease the level or effect of quetiapine by increasing the breakdown of quetiapine.
Information about Tegretol.
Caution should be exercised if alcohol is taken in combination with Tegretol therapydue to a possible additive sedative effect.
Across Asian populationsnotable variation exists in the prevalence of HLA-B*1502Greater than 15of the population is reported positive in Hong KongThailandMalaysiaand parts of the Philippinescompared to about 10in Taiwan and 4in North ChinaSouth Asiansincluding Indiansappear to have intermediate prevalence of HLA-B*1502averaging 2to 4but higher in some groupsHLA-B*1502 is present in less than 1of the population in Japan and Korea.
Patientstheir caregiversand families should be counseled that AEDsincluding Tegretolmay increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of symptoms of depressionany unusual changes in mood or behavioror the emergence of suicidal thoughtsbehavioror thoughts about self-harmBehaviors of concern should be reported immediately to healthcare providers.
If adverse reactions are of such severity that the drug must be discontinuedthe physician must be aware that abrupt discontinuation of any anticonvulsant drug in a responsive epileptic patient may lead to seizures or even status epilepticus with its life-threatening hazards.
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