Phentermine; topiramate moderate serum digoxin auc was decreased by 12 when coadministered with topiramate.

Drug interactions this medicine may interact with the following medications antifungals, central ner- vous system depressants including alcohol , digoxin, macrolides, and phenytoin.

, ethacrynic acid , cisapride, cisplatin, digoxin, ginseng, lithium, probenecid.