Bupropion should be used with caution in patients with renal impairment and a reduced frequency and or dose should be considered.

However, when this approach was translated to man, bupropion administration did not decrease striatal 11 c raclopride bp nd , indicating that extracellular dopamine levels [...]

The best evidence for bupropion is all an wetter.

In studies conducted in rats and rabbits, bupropion was administered orally at doses of up to 450 and 150 mg kg day, respectively approximately 11 and 7 times the mrhd, [...]