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The agency s guidance now recommends that physicians stop using cefixime to treat gonorrhea and instead use combination therapy with ceftriaxone, 250 mg intramuscularly, and either azithromycin, 1 g orally as a single dose, or doxycycline, 100 mg orally twice daily for seven days.
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since 2011, cefixime prescribing has fallen drastically, in line with the updated guidelines.