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If you are pregnantplanning to become pregnantor are breast-feeding if you are taking any prescription or nonprescription medicineherbal preparationor dietary supplement if you have allergies to medicinesfoodsor other substances if you have a history of heart problemsegcongestive heart failurecor pulmonalean irregular heartbeatliver problemsegcirrhosishepatitisviral infectionthyroid problemsincreased acid levels in the bodybrain or nerve problemsor seizuresegepilepsyif you are in shock or have a feveran ulcera severe infectioncystic fibrosisor fluid in the lungspulmonary edemaif you smokeare stopping or starting smokingor are exposed to the smoke from cigarettes or marijuana if you are in the last 3 months of pregnancy.

The drugs listed in Table III have either been documented not to interact with theophylline or do not produce a clinically significant interactioni.eTable IIClinically significant drug interactions with theophylline

Theophylline is safe and effective for the approved indications in pediatric patientsThe maintenance dose of theophylline must be selected with caution in pediatric patients since the rate of theophylline clearance is highly variable across the age range of neonates to adolescentssee CLINICAL PHARMACOLOGYTable IWARNINGSand DOSAGE AND ADMINISTRATIONTable VDue to the immaturity of theophylline metabolic pathways in infants under the age of one yearparticular attention to dosage selection and frequent monitoring of serum theophylline concentrations are required when theophylline is prescribed to pediatric patients in this age group.

Certain dietssuch as high protein/low carbohydrate or high carbohydrate/low proteinmay change the effect of theophyllineTell your doctor if you have any major changes in your dietYour doctor may need to adjust your dose.

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