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Patients with a Migraine AttackA migraine attack does not affect the pharmacokinetics of rizatriptan.
Rizatriptan is principally metabolized via the MAO-A subtypePlasma concentrations of rizatriptan and its active N-monodesmethyl metabolite may be increased by drugs that are selective MAO-A inhibitorse.gmoclobemideor non-selective MAO inhibitorse.gisocarboxazidphenelzinetranylcypromine and pargylineSimilar or greater effects are expected with non-selectivereversiblee.glinezolidand irreversible MAO inhibitorsIn a drug interaction studywhen rizatriptan 10 mg was administered to subjectsn=12receiving concomitant therapy with the selectivereversible MAO-A inhibitormoclobemide 150 mg t.i.dthere were mean increases in the rizatriptan AUC and C max of 119and 41respectivelythe AUC of the active N-monodesmethyl metabolite of rizatriptan was increased more than 400The interaction would be expected to be greater with irreversible MAO inhibitorsNo pharmacokinetic interaction is anticipated in patients receiving selective MAO-B inhibitorsDue to a risk of coronary artery vasoconstriction and hypertensive episodesadministration of rizatriptan to patients taking MAO inhibitors is contraindicated.
RIZACT Tablets are indicated for the acute treatment of migraine attackswith or without aurain adultsand in pediatric patients 6 to 17 years old.
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