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Lisinoprilat doses up to 1 mg/kg/daywas not teratogenic when given throughout the organogenic period in saline supplemented rabbitsSaline supplementationphysiologic saline in place of tap waterwas used to eliminate maternotoxic effects and enable evaluation of the teratogenic potential at the highest possible dosage levelThe rabbit has been shown to be extremely sensitive to angiotensin converting enzyme inhibitorscaptopril and enalaprilwith maternal and fetotoxic effects apparent at or below the recommended therapeutic dosage levels in man.
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Patients with myocardial infarction in the GISSI-3 study treated with lisinopril had a higher9.0vs 3.7incidence of persistent hypotensionsystolic blood pressure less than 90 mmHg for more than 1 hourthan patients treated with placebo.
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