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Usual dose for agitated patients with schizophrenia or bipolar mania the efficacy of intramuscular olanzapine for injection in controlling agitation in these disorders was demonstrated in a dose range of 2.
Information about Olanzapine.
Adverse reactions during exposure were obtained by spontaneous report and recorded by clinical investigators using terminology of their own choosingConsequentlyit is not possible to provide a meaningful estimate of the proportion of individuals experiencing adverse reactions without first grouping similar types of reactions into a smaller number of standardized reaction categoriesIn the tables and tabulations that followMedDRA and COSTART Dictionary terminology has been used to classify reported adverse reactions.
5-10 mg per day initiallyif necessarymay be titrated upward in increments of 5 mg per day at intervals greater than 1 week Maintenance10-20 mg per daynot to exceed 20 mg per day.
AgitationOverallthere was no difference in the incidence of discontinuation due to adverse reactions0.4for intramuscular olanzapine for injection vs 0for placebo
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it appears to produce similar epse to risperidone, asenapine and ziprasidone and more epse than olanzapine, clozapine, aripiprazole, quetiapine, amisulpride and sertindole 1 orthostatic hypotension weight gain tends to produce a moderate degree of weight gain, possibly related to its potent blockade of the 5-ht 2c receptor qt interval prolongation tends to produce less qt interval prolongation than most other atypical antipsychotics and approximately as much qt interval prolongation as aripiprazole and lurasidone 1 nasopharyngitis anxiety indigestion constipation.