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IvacaftorCo-administration with ivacaftora cystic fibrosis transmembrane conductance regulatorCFTRpotentiatorincreased ivacaftor exposure by 3-fold and hydroxymethyl-ivacaftorM1exposure by 1.9-foldA reduction of the ivacaftor dose to 150 mg once daily is recommended for patients taking concomitant moderate CYP3A inhibitorssuch as fluconazole and erythromycin.
CelecoxibDuring concomitant treatment with fluconazole200 mg dailyand celecoxib200 mgthe celecoxib C max and AUC increased by 68and 134respectivelyHalf of the celecoxib dose may be necessary when combined with fluconazole.
Your dose will depend on the infection you are treatingVaginal infections are often treated with only one pillFor other infectionsyour first dose may be a double doseCarefully follow your doctor’s instructions.
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stick with something like canesten or the diflucan oral treatment.