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Figure 1Mean Plasma Concentration-time Profile at Steady State after Multiple Dosing of Pletal 100 mg Twice Daily.
In a single-dose clinical studyno inhibition of the metabolism of warfarin or an effect on the coagulation parametersPTaPTTbleeding timewas observedHowevercaution is advised in patients receiving both cilostazol and any anticoagulant agentand frequent monitoring is required to reduce the possibility of bleeding.
Reduce dose to 50 mg twice daily when coadministered with strong or moderate inhibitors of CYP3A4e.gketoconazoleitraconazoleerythromycinand diltiazemor inhibitors of CYP2C19e.gticlopidinefluconazoleand omeprazolesee Drug Interactions7.1
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