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In one of these studies, an initial treatment with protonix i.
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More frequent side effects includediarrhea and nauseaSee below for a comprehensive list of adverse effects.
The following adverse reactions have been identified during postapproval use of Protonix and Protonix I.VBecause these reactions are reported voluntarily from a population of uncertain sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Acute interstitial nephritis has been observed in patients taking PPIs including Protonix I.VAcute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to an idiopathic hypersensitivity reactionDiscontinue Protonix I.Vif acute interstitial nephritis developssee Contraindications4
Immune System Disordersanaphylaxisincluding anaphylactic shocksystemic lupus erythematosus.
Protonix I.Vcontains edetate disodiumthe salt form of EDTAa chelator of metal ions including zincThereforezinc supplementation should be considered in patients treated with Protonix I.Vwho are prone to zinc deficiencyCaution should be used when other EDTA containing products are also co-administered intravenouslysee Dosage and Administration2.5
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protonix is not approved for use by anyone younger than 5 years old.