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Use of estrogen-aloneor in combination with a progestinshould be with the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual womanPostmenopausal women should be re-evaluated periodically as clinically appropriate to determine if treatment is still necessary.
The WHI estrogen plus progestin substudy also demonstrated an increased risk of invasive breast cancersee WARNINGS AND PRECAUTIONSand Clinical Studies
Exogenous estrogens may exacerbate symptoms of angioedema in women with hereditary angioedema.
Safety and effectiveness in pediatric patients have not been establishedEstrogen treatment of prepubertal girls induces premature breast development and vaginal cornificationand may induce uterine bleeding.
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