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Thombolytics: Th saty th concomitant administation clopidogl, ibin non-ibin spciic thombolytic agnts and hpains was assssd in patints with acut myocadial inaction. Th incidnc clinically signiicant blding was simila tthat obsvd whn thombolytic agnts and hpain a co-administd with aspiin.
Clinical and pathologic studis show that lvatd plasma lvls total cholstol (total-C), LDL-cholstol (LDL-C) and apolipopotin B (apB) pomot human athosclosis and a isk actos dvloping cadiovascula disas, whil incasd lvls HDL-cholstol (HDL-C) a associatd with a dcasd cadiovascula isk. Lik LDL, cholstol-nichd TG-ich lipopotins, including VLDL, IDL and mnants, can alspomot athosclosis. lvatd plasma TGs a quntly ound in a tiad with low HDL-C lvls and small LDL paticls, as wll as in association with non-lipid mtabolic isk actos coonay hat disas (CHD). As such, total plasma TG has not consistntly bn shown tb an indpndnt isk actCHD. uthmo, th indpndnt ct aising HDL lowing TG on th isk coonay and cadiovascula mobidity and motality has not bn dtmind.
Duc th isk non-atal MI duc th isk atal and non-atal stok duc th isk vasculaization pocdus duc th isk hospitalization CH duc th isk angina.
Oal Anti-coagulants: Th concomitant administation ATOLIP CV with oal anti-coagulants is not commndd sinc it may incas th intnsity blding. Atovastatin had nclinically signiicant ct on pothombin tim whn administd tpatints civing chonic waain tatmnt. Although th administation clopidogl 75 mg p day did not modiy th phamacokintics S-waain (a CYP2C9 substat) Intnational Nomalizd ati(IN) in patints civing long-tm waain thapy, at high concntations in vit, clopidogl inhibits CYP2C9. Co-administation ATOLIP CV with waain incass th isk blding bcaus indpndnt cts clopidogl on hmostasis.
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