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Treatment with minocycline or beta-lactam antibiotics in the preceding half year before study entry.

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Intracranial hypertensionpseudotumor cerebrihas been associated with use of tetracyclines including minocyclineavoid concomitant use of isotretinoin and minocyclineisotretinoin is also known to cause pseudotumor cerebrialthough intracranial hypertension typically resolves after discontinuation of treatmentrisk of permanent visual loss existsseek ophthalmologic evaluation if visual disturbance occurs during treatmentsince intracranial pressure can remain elevated for weeks after drug cessationmonitor until patient stabilizes.

Adultsimmediate-release tablets and capsulesThe recommended dose for minocycline is200 mg initiallyfollowed by 100 mg every 12 hoursIf more frequent doses are preferredthen two or four 50 mg capsules initiallyfollowed by 500 mg 4 times a day.

Tetracycline use during tooth developmentlast half of pregnancy through age 8 yearscan cause tooth enamel hypoplasia or permanent teeth discolorationmore common with long-term use and with repeatedshort coursesduring pregnancymay retard skeletal development and reduce bone growth.

IV200 mg IV initially followed by 100 mg IV every 12 hours Maximum dose400 mg/24 hours.

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frail or elderly patients are susceptible to the hepatotoxic and antianabolic effects of minocycline.

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