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If you are taking other medicines your doctor may need to change the dose of them to obtain the best results for you.
Numerous antihypertensive drugsfrom a variety of pharmacologic classes and with different mechanisms of actionhave been shown in randomized controlled trials to reduce cardiovascular morbidity and mortalityand it can be concluded that it is blood pressure reductionand not some other pharmacologic property of the drugsthat is largely responsible for those benefitsThe largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of strokebut reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.
Do not stop taking this medication without consulting your doctorSome conditions may become worse when you suddenly stop this drugSome people who have suddenly stopped taking similar drugs have had chest painheart attackand irregular heartbeatIf your doctor decides you should no longer use this drughe or she may direct you to gradually decrease your dose over 1 to 2 weeks.
Elevated systolic or diastolic pressure causes increased cardiovascular riskand the absolute risk increase per mmHg is greater at higher blood pressuresso that even modest reductions of severe hypertension can provide substantial benefitRelative risk reduction from blood pressure reduction is similar across populations with varying absolute riskso the absolute benefit is greater in patients who are at higher risk independent of their hypertensionfor examplepatients with diabetes or hyperlipidemiaand such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.
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