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However, ada and other clinicians currently recommend initiating therapy with metformin and adding another antidiabetic agent, such as a sulfonylurea, insulin, or a thiazolidinedione, if patients fail to achieve or maintain target hba 1c goals.
Information about Metformin.
This is not a complete list of side effects and others may occurCall your doctor for medical advice about side effectsYou may report side effects to FDA at 1-800-FDA-1088.
Your doctor or pharmacist will explain what type of metformin tablets you are on and how to take them.
Drug ClassAnti-diabeticsmedications to treat or manage diabetesBiguanides.
Have had an allergic reaction to metformin or other medicines in the past have uncontrolled diabetes have liver or kidney problems have a severe infection are being treated for heart failure or you have recently had a heart attack have severe problems with your circulation or breathing difficulties drink a lot of alcohol.
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one randomized, double-blind, 3-year trial comparing actos to glyburide as add-on to metformin and insulin therapy was specifically designed to evaluate the incidence of serum alt elevation to greater than 3 times the upper limit of the reference range, measured every 8 weeks for the first 48 weeks of the trial then every 12 weeks thereafter.