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DrowsinessDrowsiness has been reported in patients on LIORESAL INTRATHECALPatients should be cautioned regarding the operation of automobiles or other dangerous machineryand activities made hazardous by decreased alertnessPatients should also be cautioned that the central nervous system depressant effects of LIORESAL INTRATHECALbaclofen injectionmay be additive to those of alcohol and other CNS depressants.
Intrathecal BolusAfter a bolus lumbar injection of 50 or 100 mcg LIORESAL INTRATHECAL in seven patientsthe average CSF elimination half-life was 1.51 hours over the first four hours and the average CSF clearance was approximately 30 mL/hour.
LIORESAL INTRATHECAL when introduced directly into the intrathecal space permits effective CSF concentrations to be achieved with resultant plasma concentrations 100 times less than those occurring with oral administration.
Treatment Suggestions for OverdoseThere is no specific antidote for treating overdoses of LIORESAL INTRATHECALbaclofen injectionhoweverthe following steps should ordinarily be undertaken:
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the following events occurred among the 31 patients receiving lioresal intrathecal baclofen injection in two randomized, placebo- controlled trials hypotension 2 , dizziness 2 , headache 2 , dyspnea 1 .