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ProbenecidBenemidmay reduce the kidney’s removal of famciclovir leading to higher concentrations of famciclovir in the bloodThis may lead to side effects from famciclovir.
Famciclovir is as well tolerated as acyclovirComplaints of nauseadiarrheaand headache occurred in clinical trialsbut at frequencies similar to those reported by placebo recipients137 No clinically significant drug interactions have been reported to datealthough concentrations of famciclovir among volunteers increase by about 20in patients receiving concomitant cimetidine or theophylline administration138.
Prevention of herpes simplex virusHSVreactivation and treatment of recurrent episodes.
Famciclovir is an antiviral drug which is active against the Herpes virusesincluding herpes simplex 1 and 2cold sores and genital herpesand varicella-zostershingles and chickenpoxIt belongs to a class of drugs called nucleoside analogs that mimic one of the building blocks of DNAIt stops the spread of herpes virus in the body by preventing the replication of viral DNA that is necessary for viruses to multiplyOther drugs in the same class include acyclovirZoviraxand valacyclovirValtrexFamciclovir is actually aprodrugthat isnot active directly against virusesInsteadfamciclovir is converted to penciclovir in the bodyand it is the penciclovir that is active against the virusesFamciclovir is active against the same viruses as acyclovir but has a longer duration of actionThereforeit can be taken fewer times each dayFamciclovir does not cure or stop the spread of herpes infectionsFamciclovir relieves painburningitchingand tinglingand also heals and prevents sores associated with herpes infectionsFamciclovir was approved for use by the FDA in June 1994.
A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.
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in addition, two new antiviral agents, valacyclovir valtrex and famciclovir famvir , have been labeled for the treatment of genital herpes.