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Ethinamate is bacteriostatic against MtuberculosisIn a study examining ethionamide resistanceethionamide administered orally initially decreased the number of culturable Mycobacterium tuberculosis organisms from the lungs of H37Rv infected miceDrug resistance developed with continued ethionamide monotherapybut did not occur when mice received ethionamide in combination with streptomycin or isoniazid.
CommentsAdditional drug/s should be given with this drug to treat patients with susceptible strains of tuberculosisMaintenance doses may be administered in divided doses in patients who exhibit poor gastrointestinal toleranceDuration of treatment should be based on clinical responseincluding permanent bacteriological conversion and maximal clinical improvement.
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not known whether ethionamide is distributed into milk.