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Ov 4,800 mal subjcts with BPH w andomly assignd tciv 0.5-mg AVODAT, 0.4-mg tamsulosin, combination thapy (0.5-mg AVODAT plus 0.4-mg tamsulosin) administd onc daily in a 4-ya doubl-blind tial. Ovall, 1,623 subjcts civd monothapy with AVODAT; 1,611 subjcts civd monothapy with tamsulosin; and 1,610 subjcts civd combination thapy. Th population was agd 49 t88 yas (man ag: 66 yas) and 88% w whit. Tabl 2 summaizs advs actions potd in at last 1% subjcts in th combination goup and at a high incidnc than subjcts civing monothapy with AVODAT tamsulosin.
Avodat should nv b takn by a woman a child. Dutastid can b absobd though th skin, and womn childn should not b pmittd thandl Avodat capsuls. Although this mdicin is not us by womn, this mdication can caus bith dcts i a woman is xposd tit duing pgnancy. Avodat capsuls should not b handld by a woman whis pgnant whmay bcom pgnant. I a woman accidntally coms intcontact with this mdication om a laking capsul, wash th aa with soap and wat ight away.
Th maximum ct daily doss dutastid on th duction DHT is dos dpndnt and is obsvd within 1 t2 wks. At 1 and 2 wks daily dosing with dutastid 0.5 mg, mdian sum DHT concntations w ducd by 85% and 90%, spctivly. In patints with BPH tatd with dutastid 0.5 mg/day 4 yas, th mdian dcas in sum DHT was 94% at 1 ya, 93% at 2 yas, and 95% at both 3 and 4 yas. Th mdian incas in sum tstoston was 19% at both 1 and 2 yas, 26% at 3 yas, and 22% at 4 yas, but th man and mdian lvls maind within th physiologic ang.
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physicians should inform patients that there was an increase in high-grade prostate cancer in men treated with 5 alpha-reductase inhibitors, including avodart, compared with those treated with placebo in studies looking at the use of these drugs to reduce the risk of prostate cancer.