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Important safety information zoloft may cause drowsiness or dizziness.
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Studies at clinically relevant doses have demonstrated that sertraline blocks the uptake of serotonin into human plateletsIn vitro studies in animals also suggest that sertraline is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptakeIn vitro studies have shown that sertraline has no significant affinity for adrenergicalpha1alpha2betacholinergicGABAdopaminergichistaminergicserotonergic5HT1A5HT1B5HT2or benzodiazepine receptorsThe chronic administration of sertraline was found in animals to down regulate brain norepinephrine receptorsSertraline does not inhibit monoamine oxidase.
This medication may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be alert.
Both the recommended starting dosage and therapeutic range in patients with mild hepatic impairmentChild Pugh scores 5 or 6are half the recommended daily dosageSee DOSAGE AND ADMINISTRATIONThe use of ZOLOFT in patients with moderateChild Pugh scores 7 to 9or severe hepatic impairmentChild Pugh scores 1015is not recommendedSee Use In Specific PopulationsCLINICAL PHARMACOLOGY
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zoloft exists your system rapidly, 200mg takes about 4 days.