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No dosage adjustment is necessary in patients with mild hepatic diseaseThere are no data in patients with moderate or severe hepatic impairmentSince cilostazol is extensively metabolised by hepatic enzymesit is contraindicated in patients with moderate or severe hepatic impairment.
Pletal is available as 50 mg triangular and 100 mg roundwhite debossed tablets
Reduce dose to 50 mg twice daily when coadministered with strong or moderate inhibitors of CYP3A4e.gketoconazoleitraconazoleerythromycinand diltiazemor inhibitors of CYP2C19e.gticlopidinefluconazoleand omeprazolesee Drug Interactions7.1
Patients may respond as early as 2 to 4 weeks after the initiation of therapybut treatment for up to 12 weeks may be needed before a beneficial effect is experiencedIf symptoms are unimproved after 3 monthsdiscontinue PLETAL.
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