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Parkinson’s disease patients treated with dopamine agonists and other dopaminergic treatments have been reported as exhibiting impulse control disorders and compulsions like pathological gamblingincreased libidohypersexualitybinge eatingshopping and different kinds of compulsive/repetitive activitiespundingThese may also be possible with selegiline but very few cases have been reported to date.
Selegiline may be administered either as a single dose in the morning or in two divided doses of 5 mgtaken at breakfast and lunch.
Patients being treated with selegiline currently or within the past 2 weeks should receive dopamine only after careful risk-benefit assessmentas this combination enhances the risk of hypertensive reactions.
Selegiline should not be used in patients who are being treated with antidepressant drugsincluding MAO inhibitorstricyclic antidepressantsserotonin noradrenaline reuptake inhibitorsSNRIvenlafaxineand selective serotonin reuptake inhibitorse.g citalopramescitalopramfluoxetinefluvoxamineparoxetine and sertralineSee section 4.5 interactions
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