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No valid studies have been performed to assess the carcinogenicity of Danazol.
Danazol appears to exert its principal pharmacological activity in the endocrine system as an inhibitor of gonadotrophin synthesis and/or release by the pituitaryThe mechanisms by which danazol exerts its therapeutic effect are incompletely understood and there are considered to be four possible mechanisms of the action as follows:
Women who take danazol to treat endometriosis or fibrocystic breast disease should start the medication during a menstrual period.
Available evidence suggests that acute overdosage would be unlikely to give rise to immediate serious reaction.
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since hepatic dysfunction manifested by modest increases in serum transaminases levels has been reported in patients treated with danazol, periodic liver function tests should be performed see warnings and adverse reactions .