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Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practiceThe adverse reaction information from clinical trials doeshoweverprovide a basis for identifying the adverse events that appear to be related to drug use and for approximating rates.
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Concomitant administration of fluconazole at 200 mg once daily resulted in a two-fold increase in celecoxib plasma concentrationThis increase is due to the inhibition of celecoxib metabolism via P450 2C9 by fluconazolesee DRUG INTERACTIONS
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doctors wrote nearly 24 million prescriptions for celebrex and 13 million for bextra in 2004, according to fda figures.