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In a study of two subjects administered radiolabelled cardura cr 2 mg orally and 1 mg intravenously on two separate occasions, approximately 63 of the dose was eliminated in the feces and 9 of the dose was found in the urine.
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In peri- and postnatal studies in rats, postnatal development at maternal doses of 40 mg kg day or 50 mg kg day of cardura cr about 8 times human auc exposure with a 12 mg day therapeutic dose was delayed, as evidenced by slower body weight gain and slightly later appearance of anatomical features and reflexes.
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plasma elimination of cardura is biphasic, with a terminal elimination half-life of about 22 hours.