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PHYSICIANS SHOULD COMPLETELY FAMILIARIZE THEMSELVES WITH THE COMPLETE CONTENTS OF THIS LEAFLET BEFORE PRESCRIBING PLAQUENIL.
Children are especially sensitive to the 4-aminoquinoline compoundsA number of fatalities have been reported following the accidental ingestion of chloroquinesometimes in relatively small doses0.75 g or 1 g in one 3-year-old childPatients should be strongly warned to keep these drugs out of the reach of children.
MalariaThe recommended preventative adult dose is 400 mg on exactly the same day of each weekbeginning 2 weeks before exposure and continued for 8 weeks after leaving the high-risk areaChildren’s doses are based on body weight and are calculated as 5 mg of hydroxychloroquine base per kilogram of body weight to a maximum dose of 400 mg.
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one of the reasons that physicians feel comfortable in prescribing plaquenil is its low risk to benefit ratio.