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Unfortunatelydepleting the body of folate can affect healthy cellstooespecially those in the gastrointestinalGItractmouthhair follicles and liversays Prabha RanganathanMDan associate professor of medicine in the division of rheumatology at Washington University School of Medicine.
A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.
12 mg/m2 intrathecally every 2 to 5 days until the cell count of the CSF returns to normalAt this pointone additional dose is advisableAdministration at intervals of less than 1 week may result in increased subacute toxicity.
Methotrexate is ordered for a patient with a malignant tumor, methotrexate and arthritis
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some products that may interact with this drug include aliskiren, ace inhibitors such as captopril, lisinopril , angiotensin ii receptor blockers such as losartan, valsartan , cidofovir, lithium, methotrexate high-dose treatment , pemetrexed.