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Levothyroxine has a narrow therapeutic indexRegardless of the indication for usecareful dosage titration is necessary to avoid the consequences of overor under-treatmentThese consequences includeamong otherseffects on growth and developmentcardiovascular functionbone metabolismreproductive functioncognitive functionemotional stategastrointestinal functionand on glucose and lipid metabolismMany drugs interact with levothyroxine sodiumnecessitating adjustments in dosing to maintain therapeutic responsesee Drug Interactions
Iron and calcium supplements and antacids can decrease the absorption of levothyroxineThereforelevothyroxine should not be administered within 4 hrs of these products.
Dosing of levothyroxine must be individualizedYour doctor will determine the best levothyroxine dose for youwhich will likely be carefully and slowly adjustedRegular blood tests will be required to monitor your progressFollow the directions on your prescription label carefullyDo not take more or less than prescribedIt may take several weeks before you begin to notice a change in your symptomsDo not stop taking levothyroxine without talking to your doctor.
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