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Elevated systolic or diastolic pressure causes increased cardiovascular riskand the absolute risk increase per mmHg is greater at higher blood pressuresso that even modest reductions of severe hypertension can provide substantial benefitRelative risk reduction from blood pressure reduction is similar across populations with varying absolute riskso the absolute benefit is greater in patients who are at higher risk independent of their hypertensione.gpatients with diabetes or hyperlipidemiaand such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.
In patients not receiving an ACE inhibitorvalsartan-treated patients had an increase in ejection fraction and reduction in left ventricular internal diastolic diameterLVIDD
Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretionbut the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of valsartan on blood pressure.
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