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ADT is a corticosteroid dosing regimen in which twice the usual daily dose of corticoid is administered every other morningThe purpose of this mode of therapy is to provide the patient requiring long-term pharmacologic dose treatment with the beneficial effects of corticoids while minimizing certain undesirable effectsincluding pituitary-adrenal suppressionthe Cushingoid statecorticoid withdrawal symptomsand growth suppression in children.
The initial dosage of DELTASONE Tablets may vary from 5 mg to 60 mg of prednisone per day depending on the specific disease entity being treatedIn situations of less severity lower doses will generally suffice while in selected patients higher initial doses may be requiredThe initial dosage should be maintained or adjusted until a satisfactory response is notedIf after a reasonable period of time there is a lack of satisfactory clinical responseDELTASONE should be discontinued and the patient transferred to other appropriate therapyIT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENTAfter a favorable response is notedthe proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reachedIt should be kept in mind that constant monitoring is needed in regard to drug dosageIncluded in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease processthe patient’s individual drug responsivenessand the effect of patient exposure to stressful situations not directly related to the disease entity under treatmentin this latter situation it may be necessary to increase the dosage of DELTASONE for a period of time consistent with the patient’s conditionIf after long-term therapy the drug is to be stoppedit is recommended that it be withdrawn gradually rather than abruptly.
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