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Adverse Reactions Reported As Reasons For Discontinuation Of Treatment In Adult Placebo-Controlled Trials.
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SSRIs and SNRIs may impair platelet aggregation and increase the risk of bleeding eventsranging from ecchymoseshematomasepistaxispetechiaeand GI hemorrhage to life-threatening hemorrhageconcomitant use of aspirinNSAIDswarfarinother anticoagulantsor other drugs known to affect platelet function may add to this risk.
CYMBALTA treatment in placebo-controlled clinical trials across approved indicationswas associated with small mean increases from baseline to endpoint in ALTASTCPKand alkaline phosphataseinfrequentmodesttransientabnormal values were observed for these analytes in CYMBALTA-treated patients when compared with placebo-treated patientssee WARNINGS AND PRECAUTIONSHigh bicarbonatecholesteroland abnormalhigh or lowpotassiumwere observed more frequently in CYMBALTA treated patients compared to placebo.
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