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Before taking clozapinetell your doctor or pharmacist if you are allergic to it or if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.
There may be a slightly increased risk of seriouspossibly fatal side effectssuch as strokeheart failurefast/irregular heartbeatpneumoniawhen this medication is used by older adults with dementiaThis medication is not approved for the treatment of dementia-related behavior problemsDiscuss the risks and benefits of this medicationas well as other effective and possibly safer treatments for dementia-related behavior problemswith the doctor.
When there has been complete remission of psychotic symptoms for at least 2 weeksan increase in anti-parkinsonian medication is possible if indicated on the basis of motor statusIf this approach results in the recurrence of psychotic symptomsClozaril dosage may be increased by increments of 12.5 mg/week up to a maximum of 100 mg/daytaken in one or two divided dosessee above
White Blood CellWBCcounts and Absolute Neutrophil CountANCmonitoring.
Myocarditis or cardiomyopathy should be suspected in patients who experience persistent tachycardia at restespecially in the first 2 months of treatmentand/or palpitationsarrhythmiaschest pain and other signs and symptoms of heart failuree.gunexplained fatiguedyspnoeatachypnoeaor symptoms that mimic myocardial infarctionsee section 4.4
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